CAS: 5337-93-9 4-Methylpropiophenone Introduction

4-Methylpropiophenone, with CAS number 5337-93-9, also known as p-Methylpropiophenone or p-Propionyltoluene, is an important organic synthesis intermediate belonging to the aromatic ketone compounds. It is widely used in the fields of medicine, chemical industry, etc. Its molecular formula is C₁₀H₁₂O, molecular weight is 148.2, and EINECS number is 226-267-5.

This substance has distinct physical and chemical properties. Under normal temperature and pressure, it appears as a colorless to pale yellow transparent oily liquid, and may be pale yellow in some cases, with a slight aromatic odor or no obvious odor. Its core physical and chemical parameters are relatively stable: the melting point is about 7.2℃, the boiling point is between 238~239℃, the density at 25℃ is 0.993g/mL, the refractive index (n20/D) is 1.528, and the flash point is 229°F (about 108℃), showing a certain degree of stability. In terms of solubility, it is easily soluble in common organic solvents such as chloroform, hexane and ethanol, and slightly soluble in water, which makes it easy to dissolve and react in organic synthesis reactions. Chemically, the ketone carbonyl unit in its molecule has strong reactivity and can participate in various chemical transformations such as Wittig reaction and nucleophilic addition. At the same time, the benzylic C-H bond has a certain acidity due to the electron-withdrawing effect of the ketone carbonyl group, and can generate carbanions to participate in reactions under specific conditions. It should be avoided to contact with oxides, otherwise it will decompose to produce harmful substances such as carbon monoxide and carbon dioxide.

In the field of application, the main use of 4-Methylpropiophenone is as a pharmaceutical intermediate. It is a key raw material for the production of Tolperisone (a drug used to treat occlusive vascular diseases with the effects of dilating blood vessels and centrally relaxing muscles), which is of great significance for drug synthesis in the pharmaceutical industry. In addition, it can also be used as a basic reagent for organic synthesis, participating in reactions such as electrocarboxylation, and playing a role in the production of fine chemicals. At the same time, it can also be used as a photo-radical polymerization initiator, applied in the preparation of crosslinkable vinyl polymers, and has a small number of extended applications in fields such as spices and polymers.

In terms of storage and safety, this substance should be sealed, dried and protected from light under inert atmosphere and room temperature. It is usually packaged in 25kg plastic barrels or larger specifications to avoid leakage and deterioration. For safety protection, contact with skin, eyes and respiratory tract should be avoided, and appropriate protective equipment should be worn during operation. Its safety instruction is 24/25, WGK Germany grade is 3, and it is a flammable liquid. It should be stored away from fire sources and oxides. At present, many domestic enterprises supply this product, with a purity of more than 98.5%, which can meet the production and R&D needs of the pharmaceutical, chemical and other fields.