Introduction to CAS: 109555-87-5 3-(1-Naphthoyl)indole

3-(1-Naphthoyl)indole, with CAS number 109555-87-5, is an important organic compound belonging to indole derivatives. Its molecular structure consists of an indole ring and a naphthoyl group connected by a carbonyl group, with a molecular formula of C₁₉H₁₃NO and a molecular weight of 271.31. It has important application value in fields such as organic synthesis and pharmaceutical research and development.

This compound has distinct physical and chemical properties. It appears as a pale orange to pale pink crystalline solid, with a melting point of approximately 236℃, a predicted boiling point of 512.2±23.0℃, and a density of 1.267g/cm³. In terms of solubility, it is slightly soluble in organic solvents such as dimethyl sulfoxide (DMSO) and methanol, a property that makes it suitable for various organic synthesis reaction conditions. Chemically, due to the presence of functional groups such as indole ring and carbonyl group, it can undergo electrophilic substitution, oxidation and other reactions. Common oxidants include hydrogen peroxide and potassium permanganate, which provide possibilities for the synthesis of its derivatives. It should be stored in a sealed and dry environment at 2-8℃ for refrigeration to ensure its stability.

In the field of application, 3-(1-Naphthoyl)indole mainly plays a role as a key intermediate. In organic synthesis, it can be used to synthesize a variety of indole derivatives, such as 1-pentyl-3-(1-naphthoyl)indole, and is an important skeleton for constructing complex organic molecules. In the field of pharmaceutical research and development, it is an important raw material for the synthesis of potential drug molecules such as anti-tumor, anti-bacterial and anti-viral drugs. Its structural characteristics make it a high-quality building block for medicinal chemists to explore new drug candidates. In addition, it is also used in the pesticide field, which can be used to synthesize new high-efficiency and low-toxicity pesticide molecules, and can also be used as a reference standard or a special reagent component in analytical chemistry.

It should be noted that as a type of naphthoylindole compound, some derivatives of 3-(1-Naphthoyl)indole are illegally used to synthesize JWH-type synthetic cannabinoids (commonly known as "spice"). Such substances are addictive and may cause harm to human health, so many countries have imposed bans on related compounds. In legal scientific research and industrial applications, it is necessary to strictly follow relevant safety specifications, standardize operation and storage, and avoid illegal use.

At present, this compound has achieved large-scale commercial production, and there are various specifications of products available on the market, with purity mostly reaching 95% and above, meeting the application needs of different fields. Its related research is still ongoing to further expand its application prospects in legal fields.